Wednesday, 25th April 2018
25 April 2018

PG NEET Pathology MCQs 11 – Stem Cell and Genes

PG NEET Pathology MCQs 11 – Stem Cell and Genes

  1. Caspase independent program cell death

1.necrosis
2. necroptosis
3. apoptosis
4. none

Ans (3)

2. Brown atrophy is due to accumulation of

  1. melanin
  2. haemo-fuscin
  3. hematin
  4. lipofuscin

Ans (4)

3. Cell to cell permeability occurs through

  1. occludens
  2. zona adherens
  3. connexins
  4. zonulin

Ans (3)

4. Which collagen is typical of basement membrane

  1. Type 1
  2. type V
  3. type IV
  4. type III

Ans (3)

5. Peripheral proteins in cell membranes are attached by

  1. Gpl
  2. desmosomes
  3. catenins
  4. cadherins

Ans (1)

6. Stem cells are present in

  1. cornea
  2. the base of crypts
  3. bile duct of liver
  4. mesonephrons

Ans (2)

7. Linkage disequilibrium refers to

  1. never co inherited gene
  2. inherited but not with disease causing gene
  3. genetic mutation
  4. co inherited with the disease causing gene

Ans (4)

8. Gene silencing RNA

  1. rRNA
  2. tRNA
  3. mRNA
  4. none

Ans (3)

9. Functions of miRNA is

  1. gene silencing
  2. gene activation
  3. both are correct
  4. none

Ans (3)

10. FACIT collagen is

  1. type I
  2. type III
  3. type IX
  4. type XI

Ans (4)

11. The function of proteoglycans and hyaluronan is

  1. lubrication and reduces resistances
  2. cell growth
  3. connect ECM components
  4. provides tensile strength

Ans (1)

12. Which of the following is involved in stem cell self-renewal

  1. Oct3/4
  2. sox 2
  3. FLT3 ligand
  4. All the other answers are right

Ans (4)

13. True about stem cell

  1. undifferentiated
  2. pluripotent
  3. dedicated to one cell line
  4. used for cell repair and tissue
  5. can form any cell

Ans (1,2,4,5)

14. Which of the following induces apoptosis in cell

  1. oleic acid
  2. glucocorticoids
  3. isoprenoid
  4. myristic acid

Ans (3)

15. Apoptosis does not occur by normal caspase pathway in

  1. liver
  2. muscle
  3. neurons
  4. skin

Ans (3)

16. oncocytes are seen in all except

  1. pituitary
  2. thyroid
  3. thymus
  4. pancreas

Ans (3)

17. Metastatic calcification is most commonly seen in

  1. cornea
  2. extensor tendon
  3. lungs
  4. renal tubules

Ans (3)

18. Calcification in necrotic tissue is called

  1. metastatic calcification
  2. dystrophic calcification
  3. calcinosis
  4. tumoral calcinosis

Ans (2)

19. Dystrophic calcification is seen in

  1. Paget disease
  2. renal osteodystrophy
  3. atheroma
  4. milk alkali syndrome

Ans (3)

20. Location of small intestinal stem cell is

  1. jejunum epithelial cell
  2. terminal ileum mucosa
  3. crypt base
  4. mucosa throughout

Ans (3)

21. Which of the following is not correct regarding stem cell

  1. development elasticity
  2. transdifferentiation
  3. can be harvested from an embryo
  4. knock out mice made possible because of it

Ans (1)

22. Which of the following is both morphogenic and mitogenic

  1. insulin growth factor
  2. bone morphogenic factor
  3. fibroblast growth factor
  4. epidermal growth factor

Ans (2)

23. Most abundant collagen in the body

  1. type I
  2. type II
  3. type III
  4. type IV

Ans (2)

24. Genetic polymorphism includes

  1. SNP
  2. microsatellites
  3. mutation
  4. translocation
  5. mini satellites

Ans (1,2,5)

25. Collagen present in cornea

  1. type 1
  2. type 2
  3. type 4
  4. type 7

Ans (1)

26. The most common form of DNA variation is

  1. single nucleotide polymorphism
  2. copy number variations
  3. transposons
  4. mutations

Ans (1)

27. Oval stem cells are located in

  1. canal of Schlemm
  2. canal of Herring
  3. space of Disse
  4. basal lamina of myotubules

Ans (2)

28. Titin protein mutated is

  1. DCM
  2. HOCM
  3. RCM
  4. Nonfunctional cardiomyopathy

Ans (1)

29. The term pathology was coined by

  1. Robert Koch
  2. Rudolf Virchow
  3. Louis Pasteur
  4. Gregor Mendel

Ans (2)

30. Tensile strength of tendon depends on

  1. fibrillin
  2. collagen
  3. fibronectin
  4. elastin

Ans (2)

31. Which of the following function is done by a RNA in a gene

  1. knock in
  2. knock out
  3. knock down
  4. knock up

Ans (3)

32. Bridging fibrosis in large wounds is due to

  1. keratinocyte growth factor
  2. epidermal growth factor
  3. platelet derived growth factor
  4. transforming growth factor

Ans (4)

33. Human genome contains

  1. 3.2 billion DNA base pairs
  2. 2.3 billion DNA base pairs
  3. 3.2 million DNA base pairs
  4. 2.3 million DNA base pairs

Ans (1)

34. Heritable change in gene expression not caused by alteration DNA sequence refers to

  1. genetics
  2. epigenetics
  3. mutations
  4. transposons

Ans (2)

35. Epigenetics deal with genetic modification that do not alter the sequence of DNA. All of the following can detect epigenetics modification except

  1. chip on chip
  2. bisulphite method
  3. HPLC
  4. methylation specific PCR

Ans (3)

36. The most abundant glycoprotein present in the basement membrane is

  1. laminin
  2. fibronectin
  3. collagen type 4
  4. heparan sulfate

Ans (1)

37. Gap junction comprises of

  1. catenins
  2. cadherins
  3. connexins
  4. claudin

Ans (3)

38. Mutation in COL4A5 chain leads to

  1. Alport’s syndrome
  2. good Pasteur’s syndrome
  3. hereditary nonpolyposis colon cancer
  4. xeroderma pigmentosum

Ans (1)

39. Which of the following about hemopoietic stem cell is wrong

  1. stem cells have renewal property
  2. a subset of stem cells normally circulate in peripheral blood
  3. marrow derived stem cells can seed other tissues and develop into non haematopoietic cell as well
  4. stem cells resemble lymphoblasts morphologically

Ans (2)

40. True about stem cells

  1. found in yolk sac
  2. used in gene therapy
  3. terminally matured cells
  4. found in peripheral circualtion
  5. HLA DR positive

Ans (1,2,3)

41. Epidermal growth factor is formed by

  1. platelt
  2. fibroblast
  3. mast cell
  4. endothelial cells
  5. keratinocytes

Ans (5)

42. Which of the following statement is not true

  1. cytokeratin is the marker for muscle cell
  2. vimentin is used to stain fibroblasts
  3. neurofilaments are present in neurons
  4. desmin can be sued as a marker for muscle cell

Ans (1)

43. Collagen most abundant in hyaline cartilage

  1. type I
  2. type II
  3. type III
  4. type IV

Ans (2)

44. GWAS stands for

  1. genome wide association syndrome
  2. genome wide association studies
  3. genetic wide array studies
  4. genetic wide amplification studies
  5. genetic way of association atsudies

Ans (2)

45. Function of perioxiomes is

  1. protein synthesis
  2. carbohydrate metabolism
  3. generating H2O2
  4. DNA replication

Ans (3)

46. Jumping genes take part in

  1. gene regulation
  2. chromosomal aberration
  3. gene movement in a species
  4. carry out gene amplication

Ans (1)

47. Types of collagen playing important roles in wound healing

  1. I &III
  2. II&IV
  3. III&IV
  4. V&IX

Ans (1)

48. Tight junction consist of all except

  1. ocludin
  2. claudin
  3. zonulin
  4. cadherin

Ans (4)

49. Which of the following mechanism is mainly involved in genomic imprinting

  1. methylation
  2. acetylation
  3. deamination
  4. phosphorylation

Ans (1)

50. All the following are intermediate filaments except

  1. lamin
  2. cadherin
  3. vimentin
  4. desmin

Ans (2)

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