Tuesday, 24th April 2018
24 April 2018

Pharmacology Mcqs 8 – Advanced Pharmacology Anti Neoplastic Drugs

Chemotherapy, Immunosuppressants, Chelating Agents &  Advanced Pharmacology Anti-Neoplastic Drugs

  1. Methotrexate inhibits
    1. Glutathione reductase
    2. Alanine transferase
    3. Dihydrofolate Reductase
    4. Adenine deaminase
      1. Ans(3)
  2. One of the following drugs bind with tubulin & arrest the cell cycle in metaphase
    1. Vinka
    2. Nitrogen mustards
    3. Antimetabolites
    4. Alkylating agent
      1. Ans(1)
  3. Which of the following is Tyrosine Kinase Inhibitor?
    1. Infliximab
    2. Imatinib
    3. Ibutilide
    4. Idoxuridine
      1. Ans(2)
  4. All are correctly paired except
    1. Cyclophosphamide – cystitis
    2. Busulphan – pulmonary fibrosis
    3. Paclitaxel – Neurotoxicity
    4. Vincristine – Bone marrow suppression
      1. Ans(4)
  5. Antagonists of Interleukin -2 are A/E
    1. Tacrolimus
    2. Cyclosporine
    3. Mycophenolate mofetil
    4. Sirolimus
      1. Ans(3)
  6. True regarding methotrexate are A/E
    1. Folinic acid enhance its acid – cancer activity
    2. Used in psoriasis
    3. Inhibits Dihydrofolate Reductase
    4. Non – proliferative cells are resistant
      1. Ans(1)
  7. The chemotherapeutic agent of choice for Ca Oesophagus
    1. Cyclophosphamide
    2. Mercaptopurine
    3. Cisplatin
    4. Vincristine
      1. Ans(3)
  8. Gene therapy is used for A/E
    1. Gene insertion
    2. Supplementation of defective genes
    3. Blocking of expression of a particular defective gene
    4. Addition of defective gene into a normal genome
      1. Ans(4)
  9. Side – effects of cyclosporine are A/E
    1. Hypotension
    2. Nephrotoxicity
    3. Hyperkalemia
    4. Hirsutism
      1. Ans(1)
  10. The drug for methotrexate toxicity is
    1. Mesna
    2. Folic acid
    3. Folinic acid
    4. Acetylcysteine
      1. Ans(3)
  11. One of the following drugs is cardiotoxic
    1. Paclitaxel
    2. Vinblastine
    3. Adriamycin
    4. Methotrexate
      1. Ans(3)
  12. Cyclosporine inhibits
    1. T – Cells
    2. B – Cells
    3. Dendritic cells
    4. Erythropoiesis
      1. Ans(1)
  13. The enzyme used as an anticancer drug is
    1. Flutamide
    2. Finasteride
    3. L – Asparaginase
    4. Imatinib
      1. Ans(3)
  14. British Anti-Lewisite (BAL) is the DOC in
    1. Zinc Poisoning
    2. Mercury poisoning
    3. Copper poisoning
    4. Acute iron poisoning
      1. Ans(2)
  15. All are alkylating agents except
    1. Busulphan
    2. Cisplatin
    3. Procarbazine
    4. Methotrexate
      1. Ans(4)
  16. Prophylactic drug in meningococcal meningitis
    1. Penicillin
    2. Ceftriaxone
    3. Erythromycin
    4. Rifampicin
      1. Ans(4)
  17. Ceftriaxone is a
    1. First generation, oral antibiotic
    2. Third generation, parenteral antibiotic
    3. Second generation, oral antibiotic
    4. Fourth generation, parenteral antibiotic
      1. Ans(2)
  18. DOC for bacterial Vaginosis is
    1. Metronidazole
    2. Ampicillin
    3. Acyclovir
    4. Fluconazole
      1. Ans(1)
  19. DOC for herper simplex
    1. Lamivudine
    2. Ganciclovir
    3. Acyclovir
    4. Abacavir
      1. Ans(3)
  20. Bacteriostatic anti – tubercular drug is
    1. Radical cure
    2. Rifampicin
    3. Pyrazinamide
    4. Ethambutol
      1. Ans(4)
  21. Primaquine is the DOC for malaria in
    1. Radical cure
    2. Clinical cure
    3. Pregnancy
    4. Falciparum malaria
      1. Ans(1)
  22. Bull’s eye maculopathy is associated with
    1. Chloroquine
    2. Ethambutol
    3. Vancomycin
    4. Chloramphenicol
      1. Ans(1)

Read about other MCQs

Pharmacology MCQs 5 – Central Nervous System
Pharmacology MCQs 4 – Endocrinology

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